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Know All About ATM Antibody

Atm Antibody (G-12) is an excellent monoclonal Atm antibody (also known as ATM serine/threonine Kinase antibody) that is suitable for the detection of the Atm protein that is human-derived. Atm Antibody (G-12) is available in both the unconjugated anti-Atm version, and also various conjugated forms of anti-Atm antibodies, such as HRP, agarose, PE, FITC, and various Alexa fluor (r) conjugates.

The phosphatidylinositol-kinase (PIK) relatives are divided into two different subgroups. The first group includes proteins like those of the PI 3 as well as PI 4-kinases. The other group includes PIK-related kinases. The kinases that are PIK-related include Atm DNA-PKCS, Atm FRAP. You can know more about ATM/Serine-protein kinase ATM Antibody.

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They share an area of homology near their carboxy-termini, which isn't found in PI 3 as well as PI 4-kinases. Atm is a gene that causes ataxia. Atm gene is altered in the autosomal recessive disease ataxia-telangiectasia (AT) that is characterized by the degeneration of the cerebellum (ataxia) as well as the presence of blood vessels with dilated vessels (telangiectases) within the eye's conjunctiva. 

AT cells are highly sensitive to radiation from ionizing sources, but are not as effective in regulating the inhibition of DNA synthesis, and exhibit slowing in the induction of p53. Ataxia-telangiectasia Mutated (ATM) is a protein that belongs to the PI3/PI4 kinase family. 

Ataxia-telangiectasia is a rare autosomal recessive disorder characterized by progressive neurologic degeneration, immunologic deficiency, and an increased risk of lymphoid cancer. The ATM gene encodes for an enzyme that belongs to the phosphoinositide-3-kinase (PI3K) family. ATM is a protein that phosphorylates instead of cholesterol and has numerous downstream targets which act as cell-cycle regulators, including P53 Mdm2, BRCA1 and SMC1. 


What is Anti-Adiponectin Antibody?

Anti-Adiponectin can be made in rabbits using a synthetic protein that corresponds to the amino acid residues from human adiponectin. Adiponectin is an adipocyte specific protein that circulates through the bloodstream, where it makes up approximately 0.1% of all plasma protein. 

Anti- Adiponectin antigen is a member of the complement factor C1q family. Adiponectin has a carboxyl-terminal domain as well as an amino-terminal colladomain. Adipose tissue plays important role in energy storage. Adiponectin levels that are higher than normal are associated with anorexia.

It plays a vital role in physiological processes like obesity, and metabolism. Hypertension is also associated with low levels of adiponectin. Endometrial cancer risk is also linked to mutations in the gene that codes it. Adiponectin, a hormone that regulates glucose and lipid metabolism, is secreted only by adipocytes.

Adiponectin is implicated in many physiological processes, including obesity and homeostasis. Adiponectin levels that are lower than normal are associated with obesity, insulin resistance, hyperinsulinemia and other conditions such as type 2 diabetes. Adiponectin was shown to increase insulin signaling in mice, which can help with insulin resistance.

Adiponectin activates AMP, PPAR-alpha and can increase fatty acids transport, oxidation and dissipation within skeletal muscle. This results in a decrease of intramyocellular lipids and improved insulin signaling.